History
The first implementation of tomotherapy was the Corvus system developed by Nomos Corporation.[1] This was the first commercial system for planning and delivering intensity modulated radiation therapy (IMRT). The original system was designed solely for use in the brain and incorporated a rigid skull-based fixation system to prevent patient motion between the delivery of each slice of radiation. It was not long before many users eschewed the fixation system and applied the technique to tumors in many different parts of the body.
TomoTherapy, or Helical TomoTherapy, is a form of CT Guided IMRT or Intensity Modulated Radiation Therapy, which is a relatively new type of radiation therapy delivery system. The system was developed at the University of Wisconsin-Madison by professor Thomas Rockwell Mackie, Ph.D. and by freelance scientist Tomohiro Muta. A small megavoltage x-ray source was mounted in a similar fashion to a CT x-ray source, and the geometry provided the opportunity to provide CT images of the body in the treatment setup position. Although original plans were to include kilovoltage CT imaging, current models use megavoltage energies. With this combination, the unit was one of the first devices capable of providing modern image-guided radiation therapy (IGRT). The first patients were treated in 2002, at the University of Wisconsin under the guidance of Professor Minesh Mehta, M.D., under the auspices of an NIH-funded Program Project Grant.
External links
- Handbook of radiotherapy physics
- National Center for Biotechnology Information
- TomoTherapy Website
- TomoTherapy Treatment Centers
- Tomotherapy information site
- Quick overview of Tomotherapy with Video
- Cancer Management Handbook: Principles of Radiation Therapy
Case Studies
TomoTherapy® SBRT for non-small cell carcinoma
The TomoTherapy® Hi·Art® system delivers precise and effective stereotactic body radiation therapy for inoperable non-small cell lung carcinoma. Read more
TomoTherapy® Clinical Flexibility
The TomoTherapy® Hi·Art® treatment system's sophisticated delivery method allows tremendous planning flexibility and lessens the need for planning trade-offs between target coverage and critical structure avoidance. Read more
TomoTherapy® CTrue™ Adaptive Lung Case
This clinical case study demonstrates how the TomoTherapy® Hi·Art® treatment system's CTrue™ technology provides true dose guidance. Only TomoTherapy's daily 3D imaging reveals anatomical changes and their dosimetric impact at every fraction. Read more
Treating squamous cell carcinoma
An 85-year-old man with squamous cell carcinoma was facing surgical removal of his upper left jaw, eye, and socket. TomoTherapy radiation treatment spared his vision and restored his quality of life. Read more
TomoTherapy® Treatment Plan for Prostate Cancer
This simulated treatment plan demonstrates how the TomoTherapy® Hi·Art® treatment system can be used to focus the radiation dose on the target area of the prostate, while avoiding sensitive structures close by. Read more
TomoTherapy® Treatment Plan for Multiple Metastases
This simulated treatment plan demonstrates how the TomoTherapy® Hi·Art® system can be used to treat multiple lesions without the need to change isocenters. Read more
TomoTherapy® Treatment Plan for Scalp Carcinoma
This clinical case study demonstrates the TomoTherapy® Hi·Art® system's ability to treat a large, irregular lesion on the scalp in lieu of electron therapy. Read more
TomoTherapy® SBRT for Lung Metastasis
This clinical case study demonstrates the TomoTherapy® Hi·Art® system's ability to deliver stereotactic body radiation therapy (SBRT), in which very high doses are delivered to a precisely-defined target volume in a single or a few treatment fractions. A high degree of conformality and targeting accuracy are of paramount importance. Read more
TomoTherapy® Planned Adaptive™ Case
This clinical case study demonstrates the TomoTherapy® Hi·Art® treatment system's Planned Adaptive™ feature, which the clinician can use to evaluate how changes in anatomy and patient positioning impact the delivered dose. Read more
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